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If you're building an AI or machine learning startup and chasing venture capital, New York is a good place to start. We've put together an updated list of the Top 40 VC firms investing heavily in AI/ML companies, with their focus sectors, portfolio highlights, and direct contact info.

Betaworks

Location: New York, USA Founded: 2007 Fund Type: Venture Fund / Startup Studio Fund Stage: Seed, Series A, Series B Sector Focus: Artificial Intelligence & Machine Learning (AI/ML), Developer Tools, SaaS, Big Data & Analytics, Mobile, AR/VR, Consumer Tech, Creator Economy, IoT, FinTech Portfolio Highlights: Hugging Face, Bubble, IFTTT, Cube Dev, Superplastic Investments: 210 Exits: 68 **Description:**Betaworks is a New York startup studio and venture fund that builds and invests in early-stage companies sitting at the edge of technology and creativity. It backs founders working on AI/ML, SaaS, developer tools, and emerging media, the people rebuilding the internet's next era. Its bets include AI names like Hugging Face and product experiments like Bubble and IFTTT. Betaworks pairs operating help, product acceleration, and a deep community so startups can launch, scale, and carve out new categories.

Partner Contact: Josh Auerbach Email: josh@betaworks.com Website:www.betaworks.comLinkedIn:BetaworksTwitter:@betaworksFacebook:Betaworks

Blackstone Group

Location: New York, USA Founded: 1985 Fund Type: Corporate Venture Arm Fund Stage: Series B, Series C, Series D Sector Focus: Artificial Intelligence & Machine Learning (AI/ML), CloudTech, Cybersecurity, Big Data & Analytics, Developer Tools, Enterprise Software, SaaS, Risk Management, FinTech Portfolio Highlights: ShiftLeft, Ontra, IntSights, CyberGRX, Beacon Platform Investments: 182 Exits: 59 **Description:**Blackstone Group is one of the world's largest investment and advisory firms, and it puts money behind companies in enterprise software, cybersecurity, AI/ML, and fintech. Its corporate venture arm goes after later-stage startups that look ready for market leadership. The firm brings operating resources, global reach, and a lot of capital to scaling technology, including the bigger names in AI-driven security and enterprise cloud.

Partner Contact: Gregory Beutler Email: gregory.beutler@blackstone.com Website:www.blackstone.comLinkedIn:Blackstone Group

Boldstart Ventures

Location: New York, USA Founded: 2010 Fund Type: Venture Fund Fund Stage: Seed SectorFocus: Artificial Intelligence & Machine Learning (AI/ML), SaaS, CloudTech, Developer Tools, Big Data & Analytics, Enterprise Software, Information Technology Portfolio Highlights: Stellate, Slim.AI, Spectro Cloud, env0, FortressIQ, Reco Investments: 157 Exits: 23 **Description:**Boldstart Ventures is a New York seed-stage fund that backs "developer-first" and SaaS founders from day one. It leans hard into AI/ML infrastructure, enterprise cloud, and developer tools, and it helps technical founders turn early ideas into companies that define a category. With real early-stage scaling experience and a strong founder network, Boldstart has backed Stellate, FortressIQ, and Slim.AI.

Partner Contact: Natalie Ledbetter Email: natalie@boldstart.vc Website:www.boldstart.vcLinkedIn:Boldstart VenturesTwitter:@BOLDstartVCFacebook:Boldstart Ventures

BoxGroup

Location: New York, USA Founded: 2009 Fund Type: Venture Fund Fund Stage: Pre-Seed, Seed, Series A, B, C, D SectorFocus: Artificial Intelligence & Machine Learning (AI/ML), SaaS, Big Data & Analytics, Developer Tools, CloudTech, Healthcare, ClimateTech, IoT, FinTech, Consumer Tech, Robotics Portfolio Highlights: Flatiron Health, PlanetScale, Bubble, Superhuman, Capchase Investments: 559 Exits: 103 **Description:**BoxGroup is a prolific New York early-stage fund that writes checks into bold founders at the very beginning, across AI/ML, SaaS, healthcare, and fintech. It works hands-on, founder-first, and it helped launch Flatiron Health, PlanetScale, and Superhuman. Its thesis is broad, with room for artificial intelligence, machine learning, and the next round of enterprise tools.

Partner Contact: Nimi Katragadda Email: nimi@boxgroup.com Website:www.boxgroup.comLinkedIn:BoxGroupTwitter:@boxgroupFacebook:BoxGroup

City Light Capital

Location: New York, USA Founded: 2004 Fund Type: Venture Fund Fund Stage: Pre-Seed, Seed, Series A SectorFocus: Artificial Intelligence & Machine Learning (AI/ML), SaaS, Healthcare, Big Data & Analytics, Cybersecurity, IoT, ClimateTech, Productivity Tools Portfolio Highlights: Cerebral, Xage Security, Rad AI, Rune Labs, Legends of Learning Investments: 163 Exits: 16 **Description:**City Light Capital is an early-stage firm that invests in mission-driven companies working on education, safety, care, and the environment. It focuses on AI/ML, SaaS, healthtech, and IoT, backing startups that point hard technology at real human and societal problems. Rad AI and Xage Security are two of its bets, mixing AI work with actual impact.

Partner Contact: Tom Groos Email: tom@citylightcap.com Website:www.citylight.vcLinkedIn:City Light CapitalTwitter:@citylightcapFacebook:City Light Capital

Coatue

Location: New York, USA Founded: 1999 Fund Type: Venture Fund Fund Stage: Pre-Seed, Seed, Series A, B, C, D SectorFocus: Artificial Intelligence & Machine Learning (AI/ML), SaaS, FinTech, Big Data & Analytics, CloudTech, Consumer Internet, Enterprise, Developer Tools, Infrastructure, Robotics Portfolio Highlights: Deep Instinct, Domino Data Lab, Grafana Labs, Mercury, Repl.it Investments: 366 Exits: 38 **Description:**Coatue is one of the larger technology investors out there, working across public and private markets. It backs category-defining companies in AI/ML, SaaS, fintech, and enterprise software from the earliest stages through growth rounds. The approach is analytical and data-heavy, and it helps founders scale globally, with standout AI bets like Deep Instinct and Domino Data Lab.

Partner Contact: Matt Mazzeo Email: mazzeo@coatue.com Website:www.coatue.comLinkedIn:Coatue Management

Contour Venture Partners

Location: New York, USA Founded: 2005 Fund Type: Venture Fund Fund Stage: Pre-Seed, Seed, Series A SectorFocus: Artificial Intelligence & Machine Learning (AI/ML), SaaS, Big Data & Analytics, Enterprise Software, FinTech, Developer Tools, CRM, RetailTech Portfolio Highlights: SmartAsset, Wunderkind (BounceX), Slice, Movable Ink, Skopenow Investments: 159 Exits: 24 **Description:**Contour Venture Partners is a New York seed-stage fund built around enterprise SaaS, B2B SaaS, and financial services. It has moved more toward AI/ML-driven enterprise apps, backing startups in marketing tech, fintech, risk management, and data-driven business intelligence. Its portfolio includes AI-powered names like SmartAsset and Wunderkind, and it works with founders from day one.

Partner Contact: Matt Gorin Email: matt@contourventures.com Website:www.contourventures.comLinkedIn:Contour Venture Partners

Deerfield

Location: New York, USA Founded: 1994 Fund Type: Venture Fund Fund Stage: Seed, Series A, Series B SectorFocus: Artificial Intelligence & Machine Learning (AI/ML), BioTech, Healthcare, Big Data & Analytics, Pharmaceuticals, Health & Wellness, Wearables, AgTech Portfolio Highlights: LetsGetChecked, Frontier Medicines, TriNetX, Adaptive Phage Therapeutics, Element Science Investments: 244 Exits: 114 **Description:**Deerfield is a healthcare-focused investment manager working where technology meets life sciences. It backs startups using AI/ML, big data, and predictive analytics across healthcare, biotech, and wellness. Deerfield brings operating depth, strategic partnerships, and philanthropic work to help healthcare AI startups push breakthroughs that improve patient outcomes worldwide.

Partner Contact: James Flynn Email: jflynn@deerfield.com Website:www.deerfield.comLinkedIn:Deerfield Management

Dreamit Ventures

Location: New York, USA Founded: 2007 Fund Type: Venture Fund Fund Stage: Pre-Seed, Seed, Series A SectorFocus: Artificial Intelligence & Machine Learning (AI/ML), Big Data & Analytics, Healthcare, SaaS, Cybersecurity, FinTech, PropTech, Developer Tools Portfolio Highlights: EnsoData, NeuroFlow, ForMotiv, Vytalize Health, BrainCheck Investments: 383 Exits: 43 **Description:**Dreamit Ventures is a venture fund and growth platform for startups that are ready to scale, with a sharp focus on AI/ML in healthcare, security, and enterprise SaaS. It helps founders validate pilots, win customers faster, and raise follow-on capital. Its portfolio includes AI names like EnsoData and ForMotiv, betting on the next wave of AI/ML across healthcare, cybersecurity, and enterprise software.

Partner Contact: Darren Sandberg Email: darren@dreamit.com Website:www.dreamit.comLinkedIn:Dreamit VenturesTwitter:@dreamitFacebook:Dreamit Ventures

ff Venture Capital

Location: New York, USA Founded: 2008 Fund Type: Venture Fund Fund Stage: Pre-Seed, Seed, Series A, Series B SectorFocus: Artificial Intelligence & Machine Learning (AI/ML), Big Data & Analytics, Cybersecurity, FinTech, IoT, Robotics, SaaS, Telecommunications Portfolio Highlights: Plus One Robotics, Opencare, Earnest Research, JazzHR, Stocktwits Investments: 359 Exits: 28 **Description:**ff Venture Capital (ffVC) is a New York technology firm backing early-stage startups across AI/ML, cybersecurity, SaaS, and frontier areas like robotics and IoT. It does more than write checks. ffVC helps founders scale operations, recruit, and land early customers. It invests early in AI that reshapes industries from enterprise software to mobility.

Partner Contact: Conor Webb Email: conor@ffvc.com Website:www.ffvc.comLinkedIn:ff Venture CapitalTwitter:@ffvcFacebook:ff Venture Capital

FirstMark Capital

Location: New York, USA Founded: 2008 Fund Type: Venture Fund Fund Stage: Seed, Series A, Series B, Series C, Series D SectorFocus: Artificial Intelligence & Machine Learning (AI/ML), SaaS, Big Data & Analytics, Developer Tools, CloudTech, Cybersecurity, FinTech, Enterprise Software, IoT Portfolio Highlights: ActionIQ, Crossbeam, Dashlane, Guru, Upgrade Investments: 333 Exits: 52 **Description:**FirstMark Capital is one of New York's stronger early-stage firms, working with founders building AI, SaaS, fintech, and enterprise software companies. It has a solid track record behind Dashlane, Guru, and Crossbeam. FirstMark pairs operating depth, community support for founders, and scaling partnerships to get AI startups into global markets faster.

Partner Contact: Dan Kozikowski Email: dan@firstmarkcap.com Website:www.firstmarkcap.comLinkedIn:FirstMark CapitalTwitter:@firstmarkcap

Gaingels

Location: New York, USA Founded: 2015 Fund Type: Angel Network Fund Stage: Pre-Seed, Seed, Series A, Series B, Series C, Series D SectorFocus: Artificial Intelligence & Machine Learning (AI/ML), SaaS, Big Data & Analytics, FinTech, Cybersecurity, Developer Tools, Consumer Tech, HealthTech, ClimateTech Portfolio Highlights: Middesk, GrubMarket, Genies, Yieldstreet, Capchase Investments: 506 Exits: 17 **Description:**Gaingels is an angel network built around diverse and inclusive leadership teams. It invests across a lot of industries, with a growing book of AI/ML, SaaS, fintech, and climate tech startups. Gaingels combines a mission-driven community with strategic capital, so founders get funding and an influential network. Its AI/ML bets like Genies and Middesk show where it wants to go.

Partner Contact: Emilie Poteat Email: emilie@gaingels.com Website:www.gaingels.comLinkedIn:GaingelsTwitter:@gaingelsvcFacebook:Gaingels

General Atlantic

Location: New York, USA Founded: 1980 Fund Type: Venture Fund (Growth Equity) Fund Stage: Series C, Series D SectorFocus: Artificial Intelligence & Machine Learning (AI/ML), SaaS, Big Data & Analytics, FinTech, Cybersecurity, Healthcare, Enterprise Software, CloudTech, EdTech Portfolio Highlights: Incode Technologies, JumpCloud, Transmit Security, Stellar Health, Devo Investments: 405 Exits: 138 **Description:**General Atlantic is one of the bigger growth equity firms, putting capital and strategic help into high-growth companies in AI/ML, SaaS, and cybersecurity. It backs global leaders, supporting data-driven companies at later stages that are shaking up their industries with AI. Notable AI bets include Incode Technologies and Transmit Security, which keep its footprint in tech-enabled growth.

Partner Contact: Tracey Duff Email: tduff@generalatlantic.com Website:www.generalatlantic.comLinkedIn:General AtlanticTwitter:@generalatlanticFacebook:General Atlantic

General Catalyst

Location: New York, USA Founded: 2000 Fund Type: Venture Fund Fund Stage: Pre-Seed, Seed, Series A, Series B, Series C, Series D SectorFocus: Artificial Intelligence & Machine Learning (AI/ML), Big Data & Analytics, FinTech, Cybersecurity, Healthcare, ClimateTech, E-Commerce, EdTech Portfolio Highlights: Drift, Fivetran, LatchBio, Aura, Overjet Investments: 1078 Exits: 172 **Description:**General Catalyst is one of the most influential venture firms around, writing both early-stage and growth-stage checks into companies reshaping their industries through AI/ML, data, cybersecurity, and digital health. It backs mission-driven founders building companies like Drift, Fivetran, and Overjet. With operating depth and global resources, General Catalyst sticks with companies from the seed stage through IPO and past it.

Partner Contact: Jennifer Zimmerman Email: jzimmerman@generalcatalyst.com Website:www.generalcatalyst.comLinkedIn:General CatalystTwitter:@gcvpFacebook:General Catalyst

Golden Seeds

Location: New York, USA Founded: 2004 Fund Type: Angel Network Fund Stage: Pre-Seed, Seed, Series A, Series B, Series C, Series D SectorFocus: Artificial Intelligence & Machine Learning (AI/ML), SaaS, Healthcare, Big Data & Analytics, Mobile, Software, Health & Wellness Portfolio Highlights: Lark, Gummicube, Modumetal, ZineOne Investments: 102 Exits: 12 **Description:**Golden Seeds is an early-stage firm built around funding exceptional women-led businesses, and it also backs AI/ML, SaaS, and healthcare. Its aim is to pair strategic capital with mentorship for more equitable startup growth. With a real presence in AI and enterprise, Golden Seeds works with founders building scalable companies at the critical early stages.

Partner Contact: Lynn Polakoff Baine Email: lpb@goldenseeds.com Website:www.goldenseeds.comLinkedIn:Golden SeedsTwitter:@GoldenSeedsFacebook:Golden Seeds

Great Oaks Venture Capital

Location: New York, USA Founded: 2005 Fund Type: Venture Fund Fund Stage: Seed, Series A, Series B SectorFocus: Artificial Intelligence & Machine Learning (AI/ML), SaaS, Big Data & Analytics, CloudTech, Healthcare, FinTech, E-Commerce, EdTech, Mobile Portfolio Highlights: Happy Money, HealthTap, HowGood, UrbanStems, Pocket Gems Investments: 438 Exits: 102 **Description:**Great Oaks Venture Capital is a New York early-stage firm backing tech-driven startups from Seed through Series A. It invests heavily in AI/ML, SaaS, and enterprise technology, working with founders rethinking their industries with new products at scale. Its portfolio spans AI-powered platforms in fintech, edtech, healthtech, and consumer tech.

Partner Contact: Henry McNamara Email: hlmcnamara@greatoaksvc.com Website:www.greatoaksvc.comLinkedIn:Great Oaks Venture CapitalTwitter:@GreatOaksVCFacebook:Great Oaks Venture Capital

Greycroft

Location: New York, USA Founded: 2006 Fund Type: Venture Fund Fund Stage: Pre-Seed, Seed, Series A, Series B, Series C, Series D SectorFocus: Artificial Intelligence & Machine Learning (AI/ML), SaaS, Big Data & Analytics, FinTech, Cybersecurity, Developer Tools, CloudTech, E-Commerce, HealthTech Portfolio Highlights: Immuta, Spectrum Labs, Tapcart, Craft.co, Involve.ai Investments: 730 Exits: 114 **Description:**Greycroft is a top-tier venture firm investing in technology startups reshaping their industries. It has a strong presence in AI/ML, SaaS, and cloud, partnering early with founders building the next round of platforms and marketplaces. Its portfolio covers B2B SaaS, fintech, cybersecurity, healthtech, and enterprise AI, and it backs that up with strategic support and a large founder network.

Partner Contact: John Elton Email: john@greycroft.com Website:www.greycroft.comLinkedIn:GreycroftTwitter:@greycroftvcFacebook:Greycroft Partners

HOF Capital

Location: New York, USA Founded: 2015 Fund Type: Venture Fund Fund Stage: Pre-Seed, Seed, Series A, Series B, Series C, Series D SectorFocus: Artificial Intelligence & Machine Learning (AI/ML), SaaS, Big Data & Analytics, FinTech, Cybersecurity, Robotics, Healthcare, Mobile Portfolio Highlights: MoonPay, DuckDuckGo, Figment, Unqork, Flutterwave Investments: 107 Exits: 3 **Description:**HOF Capital is a global multistage venture firm with over $1 billion in assets under management, working with founders from idea to IPO. Its portfolio includes AI/ML companies in fintech, cybersecurity, productivity, and enterprise software. HOF works hands-on, mixing strategic advice, operating resources, and an international network to help AI startups expand abroad.

Partner Contact: Victor Wang Email: vwang@hof.capital Website:www.hofvc.comLinkedIn:HOF CapitalTwitter:@HOFCapital

IA Ventures

Location: New York, USA Founded: 2010 Fund Type: Venture Fund Fund Stage: Pre-Seed, Seed, Series A SectorFocus: Artificial Intelligence & Machine Learning (AI/ML), Big Data & Analytics, FinTech, SaaS, Cybersecurity, Healthcare, Information Technology Portfolio Highlights: Octane, Recorded Future, YipitData, PlaceIQ, Komodo Health Investments: 146 Exits: 28 **Description:**IA Ventures is a focused seed and early-stage firm in New York, backing companies that build an edge through AI/ML, data, and fintech. It is known for deep technical support and a founder-first stance, and it works with startups pushing predictive analytics, cybersecurity, and healthcare intelligence.

Partner Contact: Jesse Beyroutey Email: jesse@iaventures.com Website:www.iaventures.comLinkedIn:IA VenturesTwitter:@iaventuresFacebook:IA Ventures

Insight Partners

Location: New York, USA Founded: 1995 Fund Type: Venture Fund (Growth Equity & Private Equity) Fund Stage: Pre-Seed, Seed, Series A, Series B, Series C, Series D SectorFocus: Artificial Intelligence & Machine Learning (AI/ML), SaaS, Big Data & Analytics, FinTech, CloudTech, Healthcare, Cybersecurity, PropTech, E-Commerce Portfolio Highlights: Dataiku, LaunchDarkly, CertiK, MURAL, PlanetScale Investments: 910 Exits: 185 **Description:**Insight Partners is one of the most prominent growth equity firms, investing across software, internet, and AI/ML. It scales high-potential companies globally, backing founders building the next round of enterprise software, SaaS platforms, cybersecurity, and AI-powered apps. Its track record includes AI names like Dataiku, CertiK, and LaunchDarkly.

Partner Contact: Jeffrey L. Horing Email: jeffrey.horing@ncino.com Website:www.insightpartners.comLinkedIn:Insight PartnersTwitter:@insightpartnersFacebook:Insight Venture Partners

Invus

Location: New York, USA Founded: 1985 Fund Type: Venture Fund Fund Stage: Pre-Seed, Seed, Series A, Series B, Series C, Series D SectorFocus: Artificial Intelligence & Machine Learning (AI/ML), BioTech, Healthcare, Life Sciences, FinTech, Food & Beverage Portfolio Highlights: KSQ Therapeutics, Element Science, Engine Biosciences, Imvax, Cava Group Investments: 163 Exits: 49 **Description:**Invus is a global investment firm with a flexible, tailored way of building companies. It has depth in AI/ML, biotech, healthcare, and fintech, and it favors long-term relationships with founders. Its bets blend AI with advances in healthcare and life sciences, pushing on precision medicine, drug discovery, and wearables.

Partner Contact: Benjamin Tsai Email: bt@invus.com Website:www.invus.comLinkedIn:Invus

JP Morgan Chase

Location: New York, USA Founded: 2000 Fund Type: Corporate Venture Capital (CVC) Fund Stage: Series B, Series C, Series D SectorFocus: Artificial Intelligence & Machine Learning (AI/ML), SaaS, Big Data & Analytics, Cybersecurity, CloudTech, FinTech, Healthcare, Mobile, Enterprise Portfolio Highlights: Grafana Labs, Airtable, Plaid, Kensho, ReversingLabs Investments: 173 Exits: 58 **Description:**JP Morgan Chase's corporate VC arm invests in AI/ML startups and technology companies reshaping financial services. It backs AI-driven cybersecurity, enterprise SaaS, data infrastructure, and fintech, using its own industry experience to help portfolio companies scale globally and reach major markets.

Partner Contact: Beth Rockwell Email: beth.r.rockwell@jpmchase.com Website:www.jpmorganchase.comLinkedIn:JP Morgan ChaseTwitter:@jpmorganFacebook:JP Morgan Chase

Lux Capital

Location: New York, USA Founded: 2000 Fund Type: Venture Fund Fund Stage: Pre-Seed, Seed, Series A, Series B, Series C, Series D SectorFocus: Artificial Intelligence & Machine Learning (AI/ML), Big Data & Analytics, Healthcare, Robotics, DeepTech, BioTech, CloudTech, SpaceTech, Cybersecurity, SaaS Portfolio Highlights: Hugging Face, Primer, Covariant, Sourcegraph, Tecton Investments: 403 Exits: 47 **Description:**Lux Capital is a venture firm investing in founders working where science meets technology. It is committed to AI/ML, backing companies in healthcare AI, autonomous robotics, advanced analytics, and frontier tech. Its bets on Hugging Face and Covariant say a lot about how it reads AI's effect on global industries.

Partner Contact: Adam Goulburn Email: adam.goulburn@luxcapital.com Website:www.luxcapital.comLinkedIn:Lux CapitalTwitter:@Lux_CapitalFacebook:Lux Capital

NextView Ventures

Location: New York, USA Founded: 2010 Fund Type: Venture Fund Fund Stage: Pre-Seed, Seed, Series A SectorFocus: Artificial Intelligence & Machine Learning (AI/ML), SaaS, Marketplace, Big Data & Analytics, CloudTech, Developer Tools, Healthcare, FinTech, RetailTech Portfolio Highlights: Drift, Reforge, Grove Collaborative, Dia&Co, Optimus Ride Investments: 208 Exits: 37 **Description:**NextView Ventures is a seed-stage firm that invests in companies shaping a better collective future. It leans into AI/ML startups, backing bold founders building SaaS tools, smart marketplaces, and new tech products. NextView works hands-on, and its operating support has made it a trusted partner for early AI companies.

Partner Contact: Rob Go Email: rob@nextviewventures.com Website:www.nextviewventures.comLinkedIn:NextView VenturesTwitter:@NextViewVC

Operator Partners

Location: New York, USA Founded: 2020 Fund Type: Venture Fund Fund Stage: Pre-Seed, Seed, Series A SectorFocus: Artificial Intelligence & Machine Learning (AI/ML), SaaS, CloudTech, Big Data & Analytics, Developer Tools, FinTech, Healthcare, Cybersecurity, Information Technology Portfolio Highlights: Spring Health, Vendia, Material Security, Indigov, Stytch Investments: 120 Exits: 2 **Description:**Operator Partners is an early-stage firm started by experienced operators who back technical founders. It focuses on AI/ML, investing across enterprise SaaS, developer tools, healthcare AI, and the next round of cloud and cybersecurity startups. Its operator-first model means founders get tactical support in their early growth, not just a check.

Partner Contact: Olivia Benjamin Email: olivia@operatorpartners.com Website:www.operatorpartners.comLinkedIn:Operator PartnersTwitter: No official Twitter listed

OrbiMed

Location: New York, USA Founded: 1989 Fund Type: Venture Fund Fund Stage: Seed, Series A, Series B, Series C, Series D SectorFocus: Artificial Intelligence & Machine Learning (AI/ML), BioTech, Healthcare, Life Sciences, Medical Devices, Pharmaceuticals, Health & Wellness, FemTech, HR Tech, Software Portfolio Highlights: Aspen Neuroscience, Carrot Fertility, Sionna Therapeutics, XtalPi, Odyssey Therapeutics Investments: 562 Exits: 212 **Description:**OrbiMed is one of the world's largest healthcare-only investment firms. It backs companies across biopharma, AI-driven life sciences, healthcare IT, and medical devices. With decades behind it, OrbiMed brings capital and strategic depth to founders working where health, technology, and AI meet.

Partner Contact: Carl Gordon Email: gordonc@orbimed.com Website:www.orbimed.comLinkedIn:OrbiMed AdvisorsTwitter:@OrbiMed

Point72 Ventures

Location: New York, USA Founded: 2016 Fund Type: Venture Fund Fund Stage: Pre-Seed, Seed, Series A SectorFocus: Artificial Intelligence & Machine Learning (AI/ML), FinTech, Deep Tech, Cybersecurity, Big Data & Analytics, Robotics, SaaS, BioTech, Healthcare, E-Commerce, Developer Tools, Information Technology, and more. Portfolio Highlights: Shield AI, Stellar Health, Deep 6 AI, NetraDyne, Fauna Investments: 128 Exits: 11 **Description:**Point72 Ventures is a global venture firm backed by billionaire investor Steven A. Cohen. It partners early with founders building disruptive companies across fintech, deep tech, AI/ML, cybersecurity, and enterprise. The model is patient capital plus operating help, so founders can move faster on their effect on global industries.

Partner Contact: Daniel Gwak Email: daniel.gwak@point72ventures.com Website:www.p72.vcLinkedIn:Point72 VenturesTwitter:@p72vc

R/GA Ventures

Location: New York, USA Founded: 2013 Fund Type: Corporate Venture Capital Fund Stage: Seed, Series A, Series B SectorFocus: Artificial Intelligence & Machine Learning (AI/ML), Big Data & Analytics, SaaS, PropTech, IoT (Internet of Things), Software, Mobile, Advertising (AdTech), Marketing (MarTech), Healthcare, Entertainment & Media, ClimateTech & CleanTech, and more. Portfolio Highlights: Enertiv, Lytics, Cordial, Swish Analytics, PetPlate Investments: 124 Exits: 16 **Description:**R/GA Ventures is the investment arm of the global innovation consultancy R/GA. It helps incumbents act on new technology by investing in startups reshaping AI/ML, SaaS, IoT, and more. Beyond capital, it brings strategic resources, corporate partnerships, and hands-on operating support to speed up growth.

Partner Contact: Jonathan Bradley Email: jonathan.bradley@rga.com Website:ventures.rga.comLinkedIn:R/GA VenturesTwitter:@rgaventures

RRE Ventures

Location: New York, USA Founded: 1994 Fund Type: Venture Fund Fund Stage: Pre-Seed, Seed, Series A, Series B, Series C, Series D SectorFocus: Artificial Intelligence & Machine Learning (AI/ML), Big Data & Analytics, FinTech, Software, Healthcare, Cryptocurrency / Blockchain, Apps, IoT (Internet of Things), PropTech, Robotics, RetailTech, Developer Tools, and more. Portfolio Highlights: YipitData, Securrency, Braintree, Groups Recover Together, Branch Investments: 584 Exits: 120 **Description:**RRE Ventures is one of New York's original venture firms, backing entrepreneurs since 1994. It invests across a broad set of disruptive areas with a strong focus on AI/ML, FinTech, enterprise software, and emerging tech. RRE works with founders from seed to growth, bringing capital, mentorship, and strategic guidance.

Partner Contact: Will Porteous Email: will@rre.com Website:www.rre.comLinkedIn:RRE VenturesTwitter:@rre

StartUp Health

Location: New York, USA Founded: 2011 Fund Type: Venture Fund Fund Stage: Pre-Seed, Seed, Series A SectorFocus: Artificial Intelligence & Machine Learning (AI/ML), Healthcare, Health & Wellness, Elder Care, Mobile, FinTech, Enterprise, Developer Tools, Big Data & Analytics, EdTech, Life Science, and BioTech. Portfolio Highlights: Devoted Health, Fruit Street, Babyscripts, MedHaul, Particle Health, Cala Health Investments: 340 Exits: 26 **Description:**StartUp Health is a mission-driven firm investing in a global "army of Health Transformers," founders set on improving health and wellness worldwide. It focuses on AI/ML across digital health, life sciences, wellness, and elder care, supporting companies where healthcare and technology meet.

Partner Contact: Steven Krein Email: steve@startuphealth.com Website:www.startuphealth.comLinkedIn:StartUp HealthTwitter:@StartUpHealth

Stripes

Location: New York, USA Founded: 2008 Fund Type: Venture Fund Fund Stage: Seed, Series A, Series B, Series C, Series D SectorFocus: Artificial Intelligence & Machine Learning (AI/ML), Health & Wellness, Healthcare, Big Data & Analytics, Information Technology, HR Tech, Enterprise, FinTech, SaaS, Software, E-Commerce, Consumer Goods, Cybersecurity, and more. Portfolio Highlights: Hello Heart, Replicant, Verbit, Paradox, Dataiku, Novo, FullStory, Lithic, Settle, Island Investments: 110 Exits: 21 **Description:**Stripes is a growth equity firm backing forward-thinking software and consumer businesses. It invests in AI/ML startups changing healthcare, enterprise SaaS, and e-commerce. Stripes brings sector depth and a flexible investment approach to speed up growth from the early stages through scale.

Partner Contact: Jason Santiago Email: jason@stripesgroup.com Website:www.stripes.coLinkedIn:StripesTwitter:@stripesco_

The Fund

Location: New York, USA Founded: 2018 Fund Type: Venture Fund Fund Stage: Pre-Seed, Seed SectorFocus: Artificial Intelligence & Machine Learning (AI/ML), FinTech, SaaS, PropTech, Big Data & Analytics, Developer Tools, CloudTech, Consumer Internet, DeepTech, Healthcare, and more. Portfolio Highlights: DEV, Lalo, StayTuned, Huckleberry Labs Investments: 179 Exits: 4 **Description:**The Fund is a community-powered firm made up of founders and operators who invest in the next round of startups. It backs early-stage founders building AI, SaaS, and next-gen tech companies across a range of industries. With operator support and real-world insight, The Fund helps startups scale faster and smarter.

Partner Contact: Jenny Fielding Email: jenny@thefund.vc Website:www.thefund.vcLinkedIn:The FundTwitter:@TheFundGlobal

Third Kind Venture Capital

Location: New York, USA Founded: 2010 Fund Type: Venture Fund Fund Stage: Pre-Seed, Seed, Series A SectorFocus: Artificial Intelligence & Machine Learning (AI/ML), Big Data & Analytics, Healthcare, ClimateTech & CleanTech, FinTech, E-Commerce, Robotics, BioTech, Health & Wellness, Software, EdTech, and more. Portfolio Highlights: HowGood, Recurate, Lemonaid Health, Hopscotch, Pickle Robot, Envisagenics, TryNow, Hero Health Investments: 124 Exits: 20 **Description:**Third Kind Venture Capital (3KVC) does early-stage deals across a wide set of technology areas, with a strong emphasis on AI/ML. It backs companies sitting at the intersection of new technology and large markets, giving founders early funding and guidance to reach product-market fit and scale fast.

Partner Contact: Alex Binkley Email: alex@3kvc.com Website:www.3kvc.com

Thrive Capital

Location: New York, USA Founded: 2009 Fund Type: Venture Fund Fund Stage: Pre-Seed, Seed, Series A, Series B, Series C, Series D Sector**Focus:**Artificial Intelligence & Machine Learning (AI/ML), SaaS, FinTech, Big Data & Analytics, Healthcare, HR Tech, E-Commerce, CloudTech, Mobile, Enterprise, Information Technology, Advertising (AdTech), Marketing (MarTech), RetailTech, Entertainment & Media, Sports, B2B, Consumer Goods, Fashion, Cannabis, EdTech, Consulting, and more

Portfolio Highlights: Nava, LeafLink, Skims, Grailed, CommandBar, Sailthru, Scope Security, Imprint, Parafin, Otter, Mojo, Heir

Investments: 302 Exits: 63

**Description:**Thrive Capital is a New York venture firm focused on building and backing software and technology-enabled companies. It puts weight behind AI/ML, SaaS, FinTech, and HealthTech, working with founders shaping the future of their industries.

Partner Contact: Nabil Mallick Email: nabil@thrivecap.com Website:www.thrivecap.com

Tribeca Venture Partners

Location: New York, USA Founded: 2011 Fund Type: Venture Fund Fund Stage: Pre-Seed, Seed, Series A

Sector Focus:

Artificial Intelligence & Machine Learning (AI/ML), SaaS, FinTech, Big Data & Analytics, Software, Healthcare, Cryptocurrency / Blockchain, Developer Tools, Information Technology, Enterprise Solutions, EdTech, Health & Wellness, PropTech, ClimateTech & CleanTech, Robotics, Construction Tech, Collaboration Tools, Advanced Materials, Travel, Outdoors, Events, and more

Portfolio Highlights: Zebedee, Vivvi, Thinkful, Tentrr, Quantum Circuits, Crafty, AiCure, Lendio, Hive, Truveris, Toggle, Actuate

Investments: 118 Exits: 16

**Description:**Tribeca Venture Partners (TVP) is an early-stage firm in New York City, investing in companies that sit where technology meets real-world impact. With roots in SaaS, AI/ML, FinTech, and HealthTech, TVP backs digital-first founders building new solutions.

Partner Contact: Brian Hirsch Email: brian@tribecavp.com Website:www.tribecavp.com

Two Sigma Ventures

Location: New York, USA Founded: 2012 Fund Type: Venture Fund Fund Stage: Pre-Seed, Seed, Series A

**Sector Focus:**Artificial Intelligence & Machine Learning (AI/ML), Big Data & Analytics, FinTech, Healthcare, Life Science, PropTech, Infrastructure, Manufacturing, Telecommunications (TMT)

**Portfolio Highlights:**Bark Technologies, Timescale, Wristcam, Replicated, Boundless, NewtonX, Lytics, Indico Data, Kasisto, CoverWallet, Enveda Biosciences, Xilis, Hexagon Bio, and many more.

Investments: 180 Exits: 21

**Description:**Two Sigma Ventures is an early-stage fund built on Two Sigma's scientific bent. It invests in data-driven companies across AI, fintech, healthcare, life sciences, and infrastructure, working with mission-driven founders building real technology businesses.

Partner Contact: Colin Beirne Email: colin@twosigmaventures.com Website:www.twosigmaventures.com

Union Square Ventures (USV)

Location: New York, USA Founded: 2003 Fund Type: Venture Fund Fund Stage: Pre-Seed, Seed, Series A, Series B, Series C, Series D

**Sector Focus:**Artificial Intelligence & Machine Learning (AI/ML), Privacy, Software, E-Commerce, FinTech, EdTech, Logistics, Transportation, Health & Wellness, Healthcare, Big Data & Analytics, Information Technology, Marketing (MarTech), InsurTech, Developer Tools, Community, Enterprise, Cybersecurity, PropTech, Professional Services, IoT (Internet of Things), Cryptocurrency / Blockchain, ClimateTech & CleanTech, Robotics

Portfolio Highlights: DuckDuckGo, Dia&Co, Quizlet, SmartHop, CoverWallet, Yieldmo, Sofar Ocean, Slope, Bolster, Veniam, Alife, Brave Health, Simulmedia, Stack Exchange, Recount Media, and many more.

Investments: 392 Exits: 54

**Description:**Union Square Ventures is a thesis-driven firm backing trusted brands that widen access to knowledge, capital, and well-being. USV does early-stage and growth investing in areas like AI, blockchain, privacy tech, fintech, and healthcare.

Partner Contact: Albert Wenger Email: albert@usv.com Website:www.usv.com

White Star Capital

Location: New York, USA Founded: 2007 Fund Type: Venture Fund Fund Stage: Pre-Seed, Seed, Series A

**Sector Focus:**Artificial Intelligence & Machine Learning (AI/ML), FinTech, InsurTech PropTech, Healthcare, Medical Device, Enterprise, Hardware, Apps, RetailTech, Robotics, Augmented & Virtual Reality (AR/VR), Software, E-Sports (Gaming), Creator Economy, Information Technology

Portfolio Highlights: TheGuarantors, Parsley Health, KeyMe, Spatial, Sizzle, Percent

Investments: 133 Exits: 15

**Description:**White Star Capital is an international venture and early growth-stage firm backing founders building durable technology companies across AI, healthcare, fintech, proptech, and more.

Partner Contact: Nick Stocks Email: nick@whitestarvc.com Website:www.whitestarcapital.com

Winklevoss Capital

Location: New York, USA Founded: 2012 Fund Type: Family Office Fund Stage: Seed, Series A, Series B

**Sector Focus:**Artificial Intelligence & Machine Learning (AI/ML), SaaS, Healthcare, Software, E-Commerce, RetailTech, Big Data & Analytics, Developer Tools, FinTech, PropTech, Information Technology, ClimateTech & CleanTech, Delivery, Marketplace, Hospitality, Transportation, Health & Wellness, Robotics, EdTech, Consumer Goods, Fashion, Food and Beverage, Advertising (AdTech), Marketing (MarTech), CRM

**Portfolio Highlights:**Eaze, Narrativ, Caviar, Triplemint, Hydrow, Matternet, Teachable, MeUndies, Onfleet, Compology

Investments: 136 Exits: 28

**Description:**Winklevoss Capital is a family office investing in determined founders, backing AI/ML, SaaS, healthcare, fintech, consumer tech, and more. Its philosophy is about helping founders build a frictionless world.

Partner Contact: Sterling Witzke Email: sterling@winklevosscapital.com Website:www.winklevosscapital.com

XRC Labs

Location: New York, USA Founded: 2015 Fund Type: Accelerator Fund Stage: Pre-Seed, Seed, Series A

**Sector Focus:**Artificial Intelligence & Machine Learning (AI/ML), Healthcare, Health & Wellness, RetailTech, E-Commerce, Consumer Goods, Enterprise, Software, Sales Automation, Medical Device, Food and Beverage, FinTech, Mobile, Marketplace, Beauty, Logistics, B2B, Apps, Supply Chain Tech, Robotics, Consumer

Portfolio Highlights: Snappy, Recurate, Billie, Ash Wellness, Gather AI, OrthoFX, Boost, Swivel, Pod Foods Co

Investments: 114 Exits: 8

**Description:**XRC Labs is an accelerator backing the next round of disruptors in retail tech, consumer goods, healthcare, AI, and logistics. Its focus is on scaling startups that change consumer experiences and make enterprises run leaner.

Partner Contact: Diana Melencio Email: diana@xrclabs.com Website:www.xrclabs.com

Why You Should Care

AI and machine learning are among the fastest-growing areas in tech right now. Investors are putting real money behind startups applying AI to healthcare, SaaS, fintech, edtech, cybersecurity, and more.

Once you know which VCs actually write checks in your space, you can tailor your decks, personalize your outreach, and improve your odds of getting funded.

And on the subject of improving your odds.

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Conclusion

Fundraising for an AI startup doesn't have to feel like shooting arrows in the dark. Work this list of New York's top venture firms, do your homework, personalize your approach, and lock down your sensitive documents before they go out.

Good luck with your raise.

Top 40 AI & Machine Learning VC Firms in New York 2025